https://nova.newcastle.edu.au/vital/access/ /manager/Index en-au 5 Indications for single-dose activated charcoal administration in acute overdose https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14379 Wed 11 Apr 2018 13:28:54 AEST ]]> The effect of decontamination procedures on the pharmacodynamics of venlafaxine in overdose https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:14863 90) of seizure, respectively. Results: A linear logistic regression model described the data. Simulation from the model showed that the probability of seizure was 0.05 (0.03–0.08), 0.19 (0.09–0.35) and 0.75 (0.30–0.96) at 1000, 5000 and 10 000 mg, respectively (median and 95% credible interval). At the mean dose of 2100 mg the odds ratios (OR) in the presence of SDAC, WBI and SDAC/WBI were 0.48 (0.25–0.89), 0.71 (0.35–1.22) and 0.25 (0.08–0.62), respectively. A modified Gompertz model described the time to seizure events. Simulations from the Gompertz model showed that the t90 values for first seizure was 26 h and was not affected by dose or decontamination procedure. Conclusion: SDAC/WBI provided greater benefits than the sum of the independent effects of SDAC and WBI. Patients should be observed for at least 24 h for seizures based on the dose and risk of seizure occurring.]]> Sat 24 Mar 2018 08:21:09 AEDT ]]>